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Human MBL Protein, His Tag

分子别名(Synonym)

MBL,MBL2,MBP1,MBP-C,Collectin-1,COLEC1,HSMBPC,MBL2D,MBPD

表达区间及表达系统(Source)

Human MBL, His Tag (MBL-H5220) is expressed from human 293 cells (HEK293). It contains AA Glu 21 - Ile 248 (Accession # P11226-1).

Predicted N-terminus: Glu 21

蛋白结构(Molecular Characterization)

Online(Glu 21  - Ile 248) P11226-1

This protein carries a polyhistidine tag at the C-terminus.

The protein has a calculated MW of 25.9 kDa. The protein migrates as 30-33 kDa under reducing (R) condition (SDS-PAGE).

内毒素(Endotoxin)

Less than 1.0 EU per μg by the LAL method.

纯度(Purity)

>95% as determined by SDS-PAGE.

制剂(Formulation)

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

Contact us for customized product form or formulation.

重构方法(Reconstitution)

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储(Storage)

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

  1. -20°C to -70°C for 12 months in lyophilized state;
  2. -70°C for 3 months under sterile conditions after reconstitution.
 

电泳(SDS-PAGE)

Human MBL, His Tag (Cat. No. MBL-H5220) SDS-PAGE gel

Human MBL, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.

文献引用(Citations)

背景(Background)

Mannose-binding lectin (MBL) is also known as mannose-binding protein, mannan-binding protein (MBP), Mannose-binding protein C, Collectin-1 (COLEC1), MBL2, which belongs to the class of collectins in the C-type lectin superfamily. MBL contains one C-type lectin domain and one collagen-like domain. MBL has an oligomeric structure (400-700 kDa), built of subunits that contain three presumably identical peptide chains of about 30 kDa each. MBL is calcium-dependent lectin involved in innate immune defense. MBL binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. MBL binds to late apoptotic cells. MBL may bind DNA.

 

前沿进展

 
货号/价格

MBL-H5220-100ug / ¥2500

MBL-H5220-1mg (250ug X 4) / ¥15000

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MBL靶点信息
英文全称:Mannose-binding protein C
中文全称:甘露糖结合蛋白C
种类:Homo sapiens
上市药物数量:0详情
临床药物数量:1详情
最高研发阶段:临床二期
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