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Human LBP / Lipopolysaccharide Protein, His Tag

分子别名(Synonym)

Lipopolysaccharide-binding protein,LBP

表达区间及表达系统(Source)

Human Lipopolysaccharide, His Tag (LBP-H52H5) is expressed from human 293 cells (HEK293). It contains AA Ala 26 - Val 481 (Accession # P18428-1 (I465F)).

Predicted N-terminus: Ala 26

蛋白结构(Molecular Characterization)

Online(Ala 26 - Val 481) P18428-1 (I465F)

This protein carries a polyhistidine tag at the C-terminus.

The protein has a calculated MW of 52.8 kDa. The protein migrates as 62 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

内毒素(Endotoxin)

Less than 1.0 EU per μg by the LAL method.

纯度(Purity)

>95% as determined by SDS-PAGE.

制剂(Formulation)

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

Contact us for customized product form or formulation.

重构方法(Reconstitution)

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储(Storage)

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

  1. -20°C to -70°C for 12 months in lyophilized state;
  2. -70°C for 3 months under sterile conditions after reconstitution.
 

电泳(SDS-PAGE)

Human Lipopolysaccharide, His Tag (Cat. No. LBP-H52H5) SDS-PAGE gel

Human Lipopolysaccharide, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.

背景(Background)

Lipopolysaccharide-binding protein (LBP),a member of the BPI/LBP/Plunc superfamily, BPI/LBP family, is detected in blood serum. LBP plays a role in the innate immune response. Alao,LBP can bind to the lipid A moiety of bacterial lipopolysaccharides (LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria, and act as an affinity enhancer for CD14, facilitating its association with LPS. Furthermore, LBP is able to promote the release of cytokines in response to bacterial lipopolysaccharide.

 

前沿进展

 
货号/价格

LBP-H52H5-100ug / ¥3150

LBP-H52H5-1mg (500ug X 2) / ¥18000

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