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 >  Protein>FGF R4 >FG4-M52Ha

Mouse FGF R4 / CD334 Protein, His Tag

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分子别名(Synonym)

FGFR4,CD334,JTK2,MGC20292,TKF

表达区间及表达系统(Source)

Mouse FGF R4, His Tag (FG4-M52Ha) is expressed from human 293 cells (HEK293). It contains AA Leu 17 - Asp 366 (Accession # Q03142-1 ).

Predicted N-terminus: Leu 17

Request for sequence

蛋白结构(Molecular Characterization)

FGF R4 Structure

This protein carries a polyhistidine tag at the C-terminus.

The protein has a calculated MW of 40.7 kDa. The protein migrates as 55-67 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

内毒素(Endotoxin)

Less than 1.0 EU per μg by the LAL method.

纯度(Purity)

>90% as determined by SDS-PAGE.

制剂(Formulation)

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

Contact us for customized product form or formulation.

重构方法(Reconstitution)

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储(Storage)

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

  1. -20°C to -70°C for 12 months in lyophilized state;
  2. -70°C for 3 months under sterile conditions after reconstitution.
 

电泳(SDS-PAGE)

FGF R4 SDS-PAGE

Mouse FGF R4, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90%.

 

活性(Bioactivity)-ELISA

FGF R4 ELISA

Immobilized Mouse FGF R4, His Tag (Cat. No. FG4-M52Ha) at 2 μg/mL (100 μL/well) can bind Human FGF-9, Fc Tag (Cat. No. FG9-H4267) with a linear range of 0.156-5 μg/mL (QC tested).

Protocol

 

背景(Background)

Fibroblast growth factor receptor 4(FGFR4) is also known as CD334, JTK2, hydroxyaryl-protein kinase, TKF, protein-tyrosine kinase . The FGFR4 gene provides instructions for making a protein called fibroblast growth factor receptor 4. This protein is part of a family of fibroblast growth factor receptors that share similar structures and functions. These receptor proteins play a role in important processes such as cell division, regulating cell growth and maturation, formation of blood vessels, wound healing, and embryo development.The FGFR4 protein interacts with specific growth factors to conduct signals from the environment outside the cell to the nucleus. The nucleus responds to these signals by switching on or off appropriate genes that help the cell adjust to changes in the environment. In response, the cell might divide, move, or mature to take on specialized functions. Although specific functions of FGFR4 remain unclear, studies indicate that the gene is involved in muscle development and the maturation of bone cells in the skull. The FGFR4 gene may also play a role in the development and maintenance of specialized cells (called foveal cones) in the light-sensitive layer (the retina) at the back of the eye.

 

前沿进展

 
 
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FGF R4靶点信息
英文全称:Fibroblast growth factor receptor 4
中文全称:成纤维细胞生长因子受体-4
种类:Homo sapiens
上市药物数量:3详情
临床药物数量:20详情
最高研发阶段:批准上市
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