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Human TROP-2 / TACSTD2 Protein, His Tag

分子别名(Synonym)

TACSTD2,GA733-1,M1S1,TROP2

表达区间及表达系统(Source)

Human TROP-2, His Tag (TR2-H5223) is expressed from human 293 cells (HEK293). It contains AA His 27 - Thr 274 (Accession # P09758-1).

Predicted N-terminus: His 27

蛋白结构(Molecular Characterization)

Online(His 27 - Thr 274) P09758-1

This protein carries a polyhistidine tag at the C-terminus.

The protein has a calculated MW of 29.8 kDa. The protein migrates as 40-50 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

内毒素(Endotoxin)

Less than 1.0 EU per μg by the LAL method.

纯度(Purity)

>95% as determined by SDS-PAGE.

制剂(Formulation)

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

Contact us for customized product form or formulation.

重构方法(Reconstitution)

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储(Storage)

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

  1. -20°C to -70°C for 12 months in lyophilized state;
  2. -70°C for 3 months under sterile conditions after reconstitution.
 

电泳(SDS-PAGE)

Human TROP-2, His Tag (Cat. No. TR2-H5223) SDS-PAGE gel

Human TROP-2, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.

 

活性(Bioactivity)-ELISA

Biotinylated Human ELISA

Immobilized Human TROP-2, His Tag (Cat. No. TR2-H5223) at 1 μg/mL (100 μL/well) can bind Monoclonal anti-TROP-2 antibody, Human IgG1 with a linear range of 0.006-0.6 μg/mL (Routinely tested).

Protocol

背景(Background)

TROP-2 is a single-copy gene in human cells, and encodes a type-1 transmembrane glycoprotein which is over-expressed in various malignancies, also referred to as tumor associated calcium signal transducer 2 (TACSTD2), GA733-1 or M1S1. TROP-2 is related to epithelial cell adhesion molecule (EpCAM), also called TROP-1, gp40, and KSA. Trop-1 and Trop-2 are homologous to serum IGF-II-binding proteins and appear as signal transducers. Thus, they likely represent novel cell-surface receptors and may play a role in regulating the growth of carcinoma cells.

 

前沿进展

 
货号/价格

TR2-H5223-200ug / ¥2500

TR2-H5223-1mg (200ug X 5) / ¥11000

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TROP-2靶点信息
英文全称:Tumor-associated calcium signal transducer 2
中文全称:肿瘤相关钙信号传感器2
种类:Homo sapiens
上市药物数量:1详情
临床药物数量:5详情
最高研发阶段:批准上市
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