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Mouse BCMA / TNFRSF17 Protein, His Tag

分子别名(Synonym)

TNFRSF17,CD269,BCM,BCMA

表达区间及表达系统(Source)

Mouse BCMA, His Tag (BCA-M52H3) is expressed from human 293 cells (HEK293). It contains AA Met 1 - Thr 49 (Accession # O88472-1).

蛋白结构(Molecular Characterization)

Online(Met 1 - Thr 49) O88472-1

This protein carries a polyhistidine tag at the C-terminus.

The protein has a calculated MW of 7.5 kDa. The protein migrates as 13 kDa and 14 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

内毒素(Endotoxin)

Less than 1.0 EU per μg by the LAL method.

纯度(Purity)

>95% as determined by SDS-PAGE.

制剂(Formulation)

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

Contact us for customized product form or formulation.

重构方法(Reconstitution)

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储(Storage)

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

  1. -20°C to -70°C for 12 months in lyophilized state;
  2. -70°C for 3 months under sterile conditions after reconstitution.
 

电泳(SDS-PAGE)

Mouse BCMA, His Tag (Cat. No. BCA-M52H3) SDS-PAGE gel

Mouse BCMA, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.

 

活性(Bioactivity)-ELISA

Biotinylated Human ELISA

Immobilized Mouse BCMA, His Tag (Cat. No. BCA-M52H3) at 0.5 μg/mL (100 μL/well) can bind Mouse BAFF, Mouse IgG2a Fc Tag, low endotoxin (Cat. No. BAF-M5257) with a linear range of 0.2-3 ng/mL (QC tested).

Protocol

Biotinylated Human  ELISA

Immobilized Mouse BCMA, His Tag (Cat. No. BCA-M52H3) at 2 μg/mL (100 μL/well) can bind Human BAFF, Fc Tag, active trimer (Cat. No. BAF-H5261) with a linear range of 0.2-6 ng/mL (Routinely tested).

Protocol

Biotinylated Human ELISA

Immobilized Mouse BCMA, His Tag (Cat. No. BCA-M52H3) at 2 μg/mL (100 μL/well) can bind Human APRIL, Fc Tag (Cat. No. APL-H5267) with a linear range of 0.1-3 ng/mL (Routinely tested).

Protocol

背景(Background)

Tumor necrosis factor receptor superfamily member 17 (TNFRSF17) is also known as B-cell maturation protein (BCMA), CD antigen CD269, which is a member of the TNF-receptor superfamily. TNFRSF17 contains one TNFR-Cys repeat. TNFRSF17 is expressed in mature B-cells, but not in T-cells or monocytes. TNFRSF17 is receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. TNFRSF17 promotes B-cell survival and plays a role in the regulation of humoral immunity. TNFRSF17 can activate NF-kappa-B and JNK.

 

前沿进展

 
货号/价格

BCA-M52H3-100ug / ¥3500

BCA-M52H3-1mg / ¥25000

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BCMA靶点信息
英文全称:B-cell maturation protein
中文全称:B细胞成熟蛋白
种类:Homo sapiens
上市药物数量:1详情
临床药物数量:44详情
最高研发阶段:批准上市
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