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Cynomolgus / Rhesus macaque BCMA / TNFRSF17 Protein

分子别名(Synonym)

TNFRSF17,CD269,BCM,BCMA

表达区间及表达系统(Source)

Cynomolgus / Rhesus macaque BCMA (BCA-C52H7) is expressed from human 293 cells (HEK293). It contains AA Met 1 - Ala 53 (Accession # G7Q0I4-1).

Predicted N-terminus: Met 1

蛋白结构(Molecular Characterization)

BCMA(Met 1 - Ala 53) G7Q0I4-1

This protein carries a polyhistidine tag at the C-terminus.

The protein has a calculated MW of 7.9 kDa. The protein migrates as 16-20 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

内毒素(Endotoxin)

Less than 1.0 EU per μg by the LAL method.

纯度(Purity)

>90% as determined by SDS-PAGE.

制剂(Formulation)

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

Contact us for customized product form or formulation.

重构方法(Reconstitution)

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储(Storage)

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

No activity loss is observed after storage at:

  1. 4-8°C for 12 months in lyophilized state;
  2. -70°C for 3 months under sterile conditions after reconstitution.
 

电泳(SDS-PAGE)

Cynomolgus / Rhesus macaque BCMA (Cat. No. BCA-C52H7) SDS-PAGE gel

Cynomolgus / Rhesus macaque BCMA on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.

活性(Bioactivity)

Cynomolgus / Rhesus macaque BCMA (Catalog # BCA-C52H7) ELISA bioactivity

Immobilized Cynomolgus / Rhesus macaque BCMA (Cat. No. BCA-C52H7) at 0.2 μg/mL (100 μL/well) can bind Biotinylated Human BAFF, Fc Tag (Cat. No. BAF-H82F3) with a linear range of 2-16 ng/mL (QC tested).

点击申请Protocol

 

背景(Background)

Tumor necrosis factor receptor superfamily member 17 (TNFRSF17) is also known as B-cell maturation protein (BCMA), CD antigen CD269, which is a member of the TNF-receptor superfamily. TNFRSF17 contains one TNFR-Cys repeat. TNFRSF17 is expressed in mature B-cells, but not in T-cells or monocytes. TNFRSF17 is receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. TNFRSF17 promotes B-cell survival and plays a role in the regulation of humoral immunity. TNFRSF17 can activate NF-kappa-B and JNK.

参考文献(References)

Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.


货号/价格

BCA-C52H7-100ug / ¥3500

BCA-C52H7-1mg / 询价

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BCMA靶点信息
英文全称:B-cell maturation protein
中文全称:B细胞成熟蛋白
种类:Homo sapiens
上市药物数量:0详情
临床药物数量:10详情
最高研发阶段:临床二期
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