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ACROBiosystems正在积极开发更多高质量ADC药物靶点分子。如果您有任何建议或定制要求，请随时与我们联系。联系我们
图1.The purity of Human Her2, His Tag (Cat. No. HE2-H5225) was more than 90% and the molecular weight of this protein is around 80-95 kDa verified by SEC-MALS.
图2.The purity of Human EGF R, His Tag(Cat. No. EGR-H5222) was more than 90% and the molecular weight of this protein is around 90-115 kDa verified by SEC-MALS.
图3.Herceptin (Trastuzumab) captured on CM5 chip via anti-human IgG Fc antibodies surface, can bind Human Her2, His Tag (Cat. No. HE2-H5225) with an affinity constant of 1.07 nM as determined in a SPR assay.
图4.Loaded Herceptin (Trastuzumab) on AHC Biosensor, can bind Human Her2, His Tag (Cat. No. HE2-H5225) with an affinity constant of 0.825 nM as determined in BLI assay.
图5.Erbitux (Cetuximab) captured on CM5 chip via anti-human IgG Fc antibodies surface, can bind Human EGF R, His Tag (Cat. No. EGR-H5222) with an affinity constant of 1.3 nM as determined in a SPR assay.
图6.Loaded Erbitux (Cetuximab) on AHC Biosensor, can bind Human EGF R, His Tag (Cat. No. EGR-H5222) with an affinity constant of 1.23 nM as determined in BLI assay.
根据Payload作用机理的不同ACROBiosystems提供两种GlyCLICK ADC Kits
| 产品名称 | 货号 | 产品组分 |
|---|---|---|
| GlyCLICK ADC kit PNU | L1-T01-200 | enzymatic reagents for conjugation, hydrophilic and potent linker-PUN, optimized purification protocolNew |
| GlyCLICK ADC kit MMAE | L1-T02-200 | enzymatic reagents for conjugation, hydrophilic and potent linker-MMAE, optimized purification protocolNew |
GlyCILICK ADC kits偶联的ADC药物进入溶酶体后，可高效释放出毒素小分子，杀死靶细胞。
In vito cytotoxicity analysis of trastuzumab conjugated with the MMAE linker-payload using GlycLICK ADC kit MMAE. Her2+ SK-BR-3 cells were incubated with the ADC and cell viability measured with PrestoBlue after 5-6 days. Curves represent the average result from three replicates
In vito cytotoxicity analysis of trastuzumab conjugated with the PNU linker-payload using GlycLICK ADC kit PNU. Her2+ SK-BR-3 cells were incubated with the ADC and cell viability measured with PrestoBlue after 5-6 days. Curves represent the average result from three replicates
除上述ADC偶联试剂盒外，ACROBiosystems还提供同样高质量易操作的其他标记偶联试剂盒。
