【公司动态】相约圣地亚哥，抗体工程及治疗大会(有福利哦~)

Title：Mapping the Immune Response: A Precise Approach to T-Cell Receptor Sequencing and Analysis

Abstract：The T-cell receptor (TCR) repertoire plays a vital role in the immune system and its diversity directly measures immune competence. TCR diversity results from VDJ gene recombination, random insertion, deletion and substitution which generates between 1015 and 1020 clonotypes. With the advent of high-throughput sequencing technology it is now possible to sequence a large number of cells for these genes. Successful high-throughput sequencing and T-cell receptor repertoire analysis requires accurate identification of rare clonal variants and true homologous variants generated from PCR from sequencing errors.  Here, we present ClonoMap, a kit and analysis engine combining 5’ Rapid Amplification of cDNA Ends (RACE) and the incorporation of molecular barcodes to allow full-length profiling, improved quantification of clonal variants, and error-free analysis of receptor repertoire diversity. Our cloud based software analyzes raw data, annotates VDJ regions, and clusters clonotypes.  The integrated analysis engine also dynamically visualizes repertoire diversity and testing across different sequencing samples. ClonoMap is a robust and reliable research tool that can monitor T cell repertoire changes in cancer immunotherapy, autoimmune diseases, and infectious diseases.